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IUPHAR Compendium of Voltage-Gated Ion Channels 2005 |
Department of Pharmacology, University of Washington, Seattle, Washington (W.A.C.); Department of Pharmacology, University of Virginia, Charlottesville, Virginia (E.P.-R.); Biotechnology Laboratory, University of British Columbia, Vancouver, British Columbia, Canada (T.P.S.); and Abteilung Pharmakologie und Toxikologie, Institut für Pharmazie, Universität Innsbruck, Innsbruck, Austria (J.S.)
Abstract
Abstract Introduction Calcium Channel Subunits Calcium Currents Calcium Channel Genes Calcium Channel Molecular Pharmacology
The family of voltage-gated calcium channels serves as the key transducers of cell surface membrane potential changes into local intracellular calcium transients that initiate many different physiological events. There are 10 members of the voltage-gated calcium channel family that have been characterized in mammals, and they serve distinct roles in cellular signal transduction. This article presents the molecular relationships and physiological functions of these calcium channel proteins and provides comprehensive information on their molecular, genetic, physiological, and pharmacological properties.
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