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Vol. 51, Issue 3, 439-464, September 1999
NeuroPsychoPharmacologie Moléculaire, Cellulaire et
Fonctionnelle, Institut National de la Sante et de la Recherche
Medicale U288, Faculté de Médecine
Pitié-Salpêtrière, Paris, Cedex, France
I. Introduction
II. Plasma Membrane Neurotransmitter Transporters
A. Na+/Cl
-Dependent Neurotransmitter
Transporters (SCDNTs)
1. Classical Members.
2. The Orphan Transporter Subfamily.
3. Ionic Dependence and Electrogenic Properties.
4. Cellular and Subcellular Localization.
5. Phosphorylation-Dependent Regulation of Transport.
6. Pharmacological and Functional Aspects.
B. Na+/K+-Dependent Glutamate Transporters
(SKDGTs)
1. Molecular Cloning and Primary Structure.
2. Ionic Dependence and Ligand-Gated Cl Channel
Properties.
3. Cellular and Subcellular Localization.
4. Regulation of SKDGT Activity and Expression.
5. Pharmacological and Functional Aspects.
III. Vesicular Neurotransmitter Transporters (VNTs)
A. Cloning of VNTs
1. The Vesicular Monoamine Transporter (VMAT)/Vesicular
Acetylcholine Transporter (VAChT) Family.
2. Vesicular Inhibitory Amino Acid Transporter.
B. Regulation of Transport
C. Ionic Dependence and Electrogenic Properties
D. Pharmacological Properties
E. Cellular and Subcellular Localization
F. Dysfunctioning
Models for Neurodegenerative Disorders or Drug
Abuse
IV. Conclusion
Acknowledgments
References
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