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Vol. 50, Issue 2, 279-290, June 1998
Department of Pharmacology (M.P.C.), University of Dundee, Dundee,
Scotland and
Division of Physical Biochemistry (N.J.M.B.), National
Institute for Medical Research, London, England
I. Introduction
II. Nomenclature
III. Molecular Definition of Subtypes
IV. Pharmacological Definition of Subtypes
A. Antagonists
B. Allosteric Agents
C. Definition of Individual Receptor Subtypes
1. M1 receptors.
2. M2 receptors.
3. M3 receptors.
4. M4 receptors.
5. M5 receptors.
6. Functional systems whose classification is open to debate.
D. Agonists
V. Transduction Mechanisms and Functional Responses
VI. Conclusions
Acknowledgments
References
e 173, D-55216 Ingelheim/Rhein, Germany; H.J. Kilbinger,
Pharmakologisches Institut, University of Mainz, Germany; G. Lambrecht,
Department of Pharmacology, University of Frankfurt, Biocentre
Niederursel, D-60439 Frankfurt, Germany; E. Mutschler,
Department of Pharmacology, University of Frankfurt, Biocentre
Niederursel, D-60439 Frankfurt, Germany; N.M. Nathanson, Department of Pharmacology, SJ-30, University of Washington, Seattle, WA 98195, USA; R.D. Schwarz, Parke-Davis Pharmacology Research Division, 2800 Plymouth Road, Ann Arbor, MI 48105, USA.
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