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Pharmacological Reviews, Vol 18, 369-385, Copyright © 1966 by the American Society for Pharmacology and Experimental Therapeutics

B. THE LOCALIZATION OF MONOAMINERGIC BLOOD-BRAIN BARRIER MECHANISMS

A. Bertler 1, B. Falck 1, Ch. Owman 1, and E. Rosengrenn 1

1 Departments of Pharmacology, Histology and Anatomy, University of Lund

The passage of dopa and dopamine into the mouse brain has been studied with a combination of chemical determination and histochemical localization of certain monoamines and their precursors. L-Dopa, but not D-dopa or dopamine, readily penetrates into the capillary walls. These contain dopa decarboxylase and MAO, which impede the further passage of L-dopa into the brain. None of the compounds can pass into the endothelial lining of noncapillary intracerebral vessels. A free passage occurs in peripheral tissues as well as in brain areas known to be located beyond the blood-brain barrier.

The results demonstrate the existence of specialized brain barrier mechanisms at the vascular level.

Note:

The investigations were supported by grants from the Swedish Medical Research Council (Projects No. 14X-56-02, 12X-712-01, 14X-732-01, and 14X-23-01). The drugs used were generously supplied by Abbott Laboratories (Eutonyl), Swedish Ciba Ltd. (Serpasil), Ferrosan (NSD 1015, NSD 2023) and Swedish Pfizer Ltd. (Niamid).




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