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Pharmacological Reviews, Vol 18, 181-188, Copyright © 1966 by the American Society for Pharmacology and Experimental Therapeutics

D. THE STIMULATION OF GLUCONEOGENESIS FROM LACTATE BY EPINEPHRINE, GLUCAGON, AND CYCLIC 3',5'-ADENYLATE IN THE PERFUSED RAT LIVER

J. H. Exton 1 and C. R. Park 1

1 Department of Physiology, Vanderbilt University School of Medicine, Nashville, Tennessee

1. Gluconeogenesis from lactate in the perfused liver is stimulated by glucagon and the catecholamines. It is suggested that this effect has physiological significance.

2. The effect of the hormones on gluconeogenesis appears to be mediated by cyclic 3',5'-AMP.

3. The hormones (or cyclic 3',5'-AMP) activate more than one step in the pathway of lactate to glucose. The changes in the concentration of metabolic intermediates induced by the hormones are consistent with activations of phosphopyruvate carboxylase and the hexose phosphate phosphatases.




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R. L. Singhal, R. Vijayvargiya, and G. M. Ling
Cyclic Adenosine Monophosphate: Andromimetic Action on Seminal Vesicular Enzymes
Science, April 10, 1970; 168(3928): 261 - 263.
[Abstract] [PDF]


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